Will conolidine and possibly synthetic derivatives lead to a new approach for pain management that is safe, highly effective, and widely used?

This is very likely to be the case. There is a crying need for better analgesic agents that are free of serious side effects and non-addicting. The question will be to what extent this takes hold without corrupting influences or misapplied science ending up with an inferior form being offered on a wide scale commercially, as has happened many times for natural products. So, time will tell.