Recently, researchers have implicated increased production of bradykinin in patients with COVID–19 infections, and have hypothesized that a “bradykinin storm” produces more of a vascular disease that a respiratory one, causing blood clots, leaky capillaries, and inflamed blood vessels. Is bradykinin a significant factor in the pathology of this coronavirus infection?

It is one of multiple mediators that come into play, but it is significant in its own right for the reasons stated by these investigators. So this will at once point to potentially valuable treatment strategies as well as a rationale for some existing approaches that will rein in this bradykinin pathway. It is not the be-all and end-all of targets but an example of progress being made and more fully understanding what you are dealing with from this virus.