Is polydactyly in the case of having six fingers or toes, as seen occasionally by medical doctors, a different type of mutation than instances within the Ecuadoran Waorani tribe who interbred with the Anunnaki extraterrestrials, or can this also be the penetrance of an Anunnaki gene from episodes of interbreeding in other cultures?

This, interestingly enough, is always the legacy of Anunnaki interbreeding. Keep in mind this has happened in many times and places primarily as a legacy of the original bloodline that is supported and in existence to this day among the leadership of humanity, and the primary driving force for the hidden cabal that rules the Earth. There are dabblings outside this clan through dalliances, affairs, and sometimes sexual assaults with non-hybrid females, so the genetics have been distributed in many disparate humans across the globe. These influences genetically will pop up and are most readily noticed with polydactyly because it is visibly apparent. The fact that the extra digits are sometimes misshapen or malformed is not a qualitative difference stemming from a different cause altogether, but merely a consequence of the incomplete preservation of all the genetic elements in the expression resulting in a perfect anatomical representation of the Anunnaki appendage without some distortion. So this is a variable and is a consequence of the juxtaposition of the Anunnaki descendant mating with a non-descendant and then further couplings done that dilute the original genetic complement further. So the rendering will be less and less precise and become more and more a vestigial remnant of a perfect digit as occurs with normal human appendages and normal Anunnaki appendages.