Is his wife’s struggle with inner negative not only karmic, as you told us, but also a worsening as a point of vulnerability being exploited by the interlopers to target him?

This is very much the case, that her inner weaknesses are being used as a point of vulnerability to make things worse, and also to give her inner instructions deep within her mind to make you her nemesis in your thinking. So as she has inner disquiet and suffers, her first impulse is to find fault with him and blame him for her plight. This is not normal and that is what he is sensing, that there is something unnatural about it all. The answer, as you know from helping many in this situation, is, indeed, the work you and he are pursuing with the Lightworker Healing Protocol and the Deep Subconscious Channeling resource, to work on the inner obstacles to healing. That can help both him and his wife, greatly, because the stronger each of you become, the less effective will be the consequences of any targeting, whether of you directly, or those around you. You can learn and adapt to become independent and relatively insulated from the negativity of others. And it is especially true, that vigorous prayer work and use of the LHP build increasing layers of divine insulation to head off the inclination to target again and again, and lessen the frequency, to eventually be dropped from the list. That is always the goal but takes some time and is not a quick solution. In the meantime, staying strong and doing the healing work is the best answer to help keep you going and not go under. There is always light at the end of the tunnel, if you can stay on your own two feet and get there.