How accurate and reliable is the May 2024 paper in the journal Nature Medicine claiming that the presence of two copies of the APOE4 gene significantly increases the risk of developing Alzheimer’s disease through mechanisms involving gene dose dependent risk, toxic effects, loss of protective functions, and impact on amyloid pathology? This research suggests the APOE4 gene is a genetic cause of this disease, not merely a risk factor indication. Although these findings are disputed, is this research connected to the recently approved Alzheimer’s treatment Leqembi from Eisai and Biogen, a drug that removes amyloid from the brain? How beneficial will Leqembi be as a treatment for Alzheimer’s?

We have described quite carefully, through your channel's probing questions, the true origin of Alzheimer's disease. So any genetic alteration that has an association to a predisposition for dementia might be a contributing factor, in terms of vulnerability to the consequence of a viral incursion to get the disease process started, but will not be in and of itself a cure or a fruitful avenue for further research. There are many risk factors that will help determine whether or not the same virus that causes Alzheimer's in one person leaves another symptom-free for a lifetime despite the presence within the brain. If there were one point of vulnerability that could be corrected, say with gene therapy, that would be one thing, but you are far from being able to control all the variables here in the face of a viral onslaught that could be a karmic tsunami and unstoppable. So this is one of many, many scientific conjectures that have been promoted as "the answer for Alzheimer's" which are more wishful thinking than fruitful avenues for research. Such things are promoted avidly by the interlopers who do not want you to know the true cause being their biowarfare campaign to instill harmful viruses in the human population that cause all kinds of chronic illness. We have also commented quite clearly that the existence of amyloid plaques and tangles are not the cause of illness but a downstream consequence, so any therapy designed to reduce the presence of these pathologic changes will have a modest benefit, at best, in slowing progression of symptoms perhaps, but not preventing or reversing the disease.