He asks: “Was his wife a targeted individual, or was it strictly a psychological problem?”

She had her own karmic difficulties and vulnerabilities and, unfortunately, was vulnerable to being harmed in ways that could lead to her suicide. As such, she was a convenient device that could be used to torment your friend through causing her to suffer an eventual demise, leaving him feeling guilty and alone. As such, she was simply a pawn, as this is typical in the strategies used to harm targeted individuals. It is standard practice to harm people around a target, because they know it will cause the targeted person to suffer to see those they care about having problems they cannot do anything about, and that failure will add to the suffering. So this is a delicate matter that is not for his ears. It is very difficult when one already feels guilt and regret to learn their targeting caused the deaths of others. The lesson here is, humanity needs to deal with the interlopers once and for all to end the madness. It is too big a problem for individuals to do much about.