A recent review of medical research by J. Moncrieff, et al. in Molecular Psychiatry (Molecular Psychiatry; https://doi.org/10.1038/s41380-022-01661-0) was summarized as follows: “This review suggests that the huge research effort based on the serotonin hypothesis has not produced convincing evidence of a biochemical basis to depression. This is consistent with research on many other biological markers [21]. We suggest it is time to acknowledge that the serotonin theory of depression is not empirically substantiated.” Was that a correct conclusion? Is the medicinal use of SSRIs as anti-depressants misguided?

This was a correct conclusion and it is also true that the use of selective serotonin reuptake inhibitors for depression is misguided, and given there are complications and side effect issues, this calls into question the entire medical thesis of treating problems of the mind with chemical substances. We have told you before, this is a misguided approach. There are certainly times when having a band-aid is better than nothing, but when you are dealing with chronic maladies like clinical depression, with its great toll on productivity and human happiness as well as longevity, given increased suicide rates and other complications in promoting a debilitating downward trajectory with aging among depressed people, this cries out for a better fundamental understanding of the dynamics of depression. You have ferreted out the true causes of depressive illness, for the most part being karmic and sometimes exacerbated by the presence of dark spirit possession, creating a chronic siege going on within the deep subconscious, that literally wears a person down and out, to the point they are ready to give up, without consciously being aware of all that inner torment creating that dire emotional state of depletion. This is a further validation of the wisdom of your choice you made, more than 20 years ago, to walk away from a research career in drug discovery, when you were moved into a neuroscience division and you knew intuitively that the chemical imbalance theory, to explain anxiety and depression, not to mention the vague and uncertain causes of dementia, were fraught with difficulty, and likely ultimate failure, in providing an avenue to unearth effective new drug therapies—you were right, and we congratulate your acumen! This is a good illustration of the value of having a profound intuitive reach, even without a conscious awareness it is going on. You knew internally, "the emperor had no clothes," but perceived it more as an inner caution that might only be fear of failure, but nonetheless you saw it very clearly as starting over, and at the bottom as well, and that was a very good characterization because medical science has not begun to truly come to grips with problems of the mind. So it is interesting, and we feel should be rewarding to you in realizing not only were you right and the mainstream science wrong, you have, through your own independent research, pointed the way towards solutions for all of these mental problems, and this can change the entire field of medical research for problems of the mind, once your information becomes more widely known by those able to think clearly, and truly see the possibilities, without being manipulated to stay within the narrow thinking and mindset of conventional medicine of today.