The interconnectedness very much is an operating condition, and so the interchange and interplay are very involved and dynamic and ongoing beyond conscious awareness but is nonetheless real and nonetheless important. So the effect of a prayer request on a sufferer is governed by many factors, their willingness to heal on all levels, each having a voice and a vote in a sense, as well as the soul plan as governed by the higher self, which monitors things and coordinates the giving of life force energy and other healing interventions, the standing of the one making the prayer request with respect to their belief and their belief in themselves, and having a voice with Creator, are all important factors and variables as well.
If a person prays who has little belief in the divine, but, is doing so out of desperation, their prayer will have less likelihood of success. This is how it must be, for you are in charge, and therefore, the strength and purity of intention, and the extent of belief, all are important governing factors in whether we can respond to the request and deliver what is requested in full measure. You all have standing, you all have power, but you may choose to undermine this and limit your power and effectiveness.
The same is true on the receiving end. If someone does not believe in themselves and has decided they are doomed, then prayers on their behalf may not be sufficient to change this fate, for they ultimately are the ruler of their kingdom and their word is law, even when misguided or corrupted or distorted through a poorly functioning brain. These factors are weighed and can allow some leeway in having a strong prayer override indecisiveness and some degree of doubt. Therefore it is important to have an advocate, and often times have more than one person involved in a prayer effort, for the belief quotients can be added together to make up for a shortfall. It may take two people praying to make up for the very low belief in a sufferer who has given up on God, so to speak, and thereby begun to close the door to the possibility of divine intervention.
There is a calculation involved here as to the various ingredients in the recipe for a solution to a dilemma, but among the many factors, all comes back to having enough outreach from the human side to Creator to allow the possibility of divine intervention in the first place, for without the human request, nothing will happen.
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