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The Lancet just published a 96,000-patient registry analysis of multinational clinical data from hospitalized patients with COVID-19 comparing outcomes of four non-randomized treatment groups compared to controls: Chloroquine alone, chloroquine with a macrolide, hydroxychloroquine alone, or hydroxychloroquine with a macrolide. The main endpoints were in-hospital mortality and sustained ventricular tachycardia or ventricular fibrillation. There was no confirmed benefit of any treatment, and each of these drug regimens were associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias. Despite the fact this was not a careful randomized trial, it has been widely touted by the press, condemning the use of hydroxychloroquine as not only useless but dangerous for COVID-19 therapy. What is your interpretation of these data?
ClosedNicola asked 4 years ago • 
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