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How accurate and reliable is the May 2024 paper in the journal Nature Medicine claiming that the presence of two copies of the APOE4 gene significantly increases the risk of developing Alzheimer’s disease through mechanisms involving gene dose dependent risk, toxic effects, loss of protective functions, and impact on amyloid pathology? This research suggests the APOE4 gene is a genetic cause of this disease, not merely a risk factor indication. Although these findings are disputed, is this research connected to the recently approved Alzheimer’s treatment Leqembi from Eisai and Biogen, a drug that removes amyloid from the brain? How beneficial will Leqembi be as a treatment for Alzheimer’s?
ClosedNicola asked 6 months ago • 
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